Nootropic Peptides
Peptides for cognitive enhancement, neuroprotection, and brain health. From BDNF-boosting peptides to neuroprotective compounds being studied for neurodegenerative diseases.
Category Overview
Nootropic peptides enhance cognitive function through several mechanisms: increasing brain-derived neurotrophic factor (BDNF), promoting neurogenesis (new neuron formation), modulating neurotransmitter systems, and protecting neurons from oxidative damage.
Unlike traditional nootropics (caffeine, racetams), peptide nootropics often target growth factor pathways rather than directly stimulating neurotransmitter release. This may provide more sustainable cognitive enhancement with less tolerance buildup, though the research is still maturing.
Semax and Selank stand out as the most clinically validated nootropic peptides, with government-backed approval in Russia. Western clinical trials are limited but interest is growing, particularly for neuroprotective applications in aging and neurodegenerative disease.
All Nootropic Peptides
Synthetic ACTH fragment developed in Russia. Approved there for stroke recovery, cognitive impairment, and ADHD. Enhances BDNF expression and modulates serotonin/dopamine. Administered intranasally.
Synthetic tuftsin analog with anxiolytic and nootropic properties. Approved in Russia for anxiety and cognitive enhancement. Modulates GABA, serotonin, and immune function. Nasal administration.
Angiotensin IV analog that dramatically increases synaptic connectivity and BDNF signaling. Showed potent cognitive enhancement in animal models — reportedly 10 million times more potent than BDNF. Very early research.
TREK-1 channel blocker derived from sortilin. Antidepressant and potential cognitive effects in animal models. Works through a novel mechanism distinct from traditional antidepressants.
Neuroprotective properties have been demonstrated in animal models — protects against dopaminergic neurotoxicity, promotes nerve healing, and may support brain-gut axis function.
Peptide mixture derived from pig brain tissue. Approved in many countries for stroke, traumatic brain injury, and dementia. Contains neurotrophic peptide fragments. IV administration required.
Synthetic peptide mimicking cerebrolysin's active component. Promotes neurogenesis in the hippocampus. Easier to manufacture and dose than full cerebrolysin. Intranasal delivery.
Mitochondrial-derived peptide with potent neuroprotective effects. Protects neurons from amyloid-beta toxicity (relevant to Alzheimer's). Levels decline with age and in neurodegenerative disease.
Disclaimer: Most nootropic peptides are not FDA-approved in the United States. Cognitive enhancement claims are based on limited research. This information is for educational purposes only. Do not self-medicate with research peptides for cognitive enhancement.