Weight Loss Peptides
GLP-1 receptor agonists have revolutionized weight management. This category covers all peptides used for weight loss — from FDA-approved drugs like semaglutide and tirzepatide to emerging therapies and research compounds.
Category Overview
Weight loss peptides primarily work by mimicking GLP-1, a gut hormone that suppresses appetite and improves metabolic function. The field has evolved rapidly: from first-generation daily injections (liraglutide) to weekly injections (semaglutide, tirzepatide) to upcoming oral options (orforglipron). Newer drugs target additional receptors (GIP, glucagon) for greater efficacy.
FDA-approved options produce 8-23% average body weight loss, with next-generation drugs in clinical trials showing even greater potential. For a comprehensive overview, see our Peptides for Weight Loss guide.
All Weight Loss Peptides
Dual GLP-1/GIP agonist. Produces up to 22.5% weight loss. FDA-approved as Mounjaro (diabetes) and Zepbound (obesity).
GLP-1 agonist with proven cardiovascular benefits. Up to 15% weight loss. Available as Ozempic, Wegovy, and Rybelsus (oral).
Triple agonist (GLP-1/GIP/glucagon) showing up to 24.2% weight loss in Phase 2. Could become the most effective weight loss peptide.
Growth hormone fragment (aa 177-191) studied for fat reduction. Failed Phase 3 trials but remains popular in wellness clinics.
First-generation daily GLP-1 agonist. ~8% average weight loss. Largely superseded by semaglutide and tirzepatide but still available.
Dual GLP-1/glucagon agonist by Boehringer Ingelheim. Up to 19% weight loss in Phase 2 plus significant liver fat reduction. Phase 3 ongoing.
Non-peptide oral GLP-1 agonist by Eli Lilly. Could eliminate need for injections entirely. Phase 3 results expected 2026.
Combination of semaglutide + cagrilintide (amylin analog) by Novo Nordisk. Phase 3 showed ~22.7% weight loss, rivaling tirzepatide.
Key Comparisons
Related Guides
Disclaimer: Weight loss peptides are prescription medications that should only be used under medical supervision. This page is for informational purposes only and does not constitute medical advice. Consult your healthcare provider to determine which treatment is appropriate for your situation.