Selank Dosage Guide: Intranasal and Injection Protocols
Selank is a short anxiolytic peptide developed in Russia as an analog of the immunopeptide tuftsin, and like Semax it is used clinically there, which means its dosing is better documented than most research peptides but still sits outside the FDA framework. This guide covers the standard anxiolytic doses, the intranasal and subcutaneous routes, reconstitution for a nasal sprayer, timing, cycling, and how it pairs with Semax. For the background pharmacology, start with the Selank peptide overview.
Selank Dosage Chart: Quick Reference
The doses below reflect the common anxiolytic range. Russian clinical protocols anchor near 450 mcg per day; nootropic users often run a little higher, up to 900 mcg. Almost everyone lands in the 300 to 900 mcg daily band.
| Protocol | Dose | Route | Frequency | Best For |
|---|---|---|---|---|
| Beginner | 300 mcg | Intranasal | Once daily | First-time users |
| Standard anxiolytic | 600–900 mcg | Intranasal | 300 mcg, 2–3× daily | Daytime anxiety |
| Subcutaneous | 250–300 mcg | Injection | Once or twice daily | Predictable delivery |
The Standard Anxiolytic Dose
For anxiety and general calm, the reference is 300 mcg per application taken one to three times a day, for a daily total of 300 to 900 mcg. A reasonable way to begin is a single 300 mcg dose for the first few days to see how you respond, then adding a second or third application if it is well tolerated and you want a stronger effect. The registered Russian nasal course sits near 450 mcg per day, which is a good midpoint to aim for before deciding whether to go higher.
Intranasal Protocol and Reconstitution
Selank is sold as a lyophilized powder, and the nasal route is the most common. The stable form for nasal use is N-acetyl Selank amidate. Reconstitute a 10 mg vial with about 2 mL of bacteriostatic water to get a 5 mg/mL solution. At that strength a 0.1 mL spray carries roughly 500 mcg, which is above a single dose, so many users either dilute further with more bacteriostatic water or use a metered dropper to hit closer to 300 mcg per application. Swirl to mix, do not shake, and refrigerate. The storage rules in our peptide storage guide apply. The Selank nasal spray guide covers sprayer setup in more detail.
Subcutaneous Dosing
Injection is the alternative to the nasal spray and gives more consistent delivery, since nasal absorption swings with congestion and technique. Subcutaneous doses sit around 250 to 300 mcg per administration. The mechanics are the same as any small-volume subcutaneous peptide; the technique in how to inject peptides carries over. Most people stay nasal for convenience and switch to injection only when they want reproducible dosing.
Timing
Selank is not stimulating, so timing is flexible. Most people dose during the day when anxiety tends to build, and because it does not sedate, it can go before work or tasks that need calm focus. Unlike a stimulating peptide, an evening dose does not typically disrupt sleep, so it can also be used to wind down. Space multiple doses across the day rather than stacking them.
Cycling
A common cycle is around 14 days, which tracks the clinical dosing literature, with some research protocols extending to 30 days. Selank does not appear to produce the tolerance or dependence associated with benzodiazepines, so cycling is used mainly to reassess whether the effect is still meaningful against baseline rather than to restore sensitivity. Continuous use beyond a month is reported but has thinner safety data behind it, so breaks are the conservative default.
Stacking with Semax
The Selank and Semax pairing is the classic nootropic stack. Selank leans calming and anti-anxiety while Semax pushes alertness and focus, so they balance each other; people run them together in the morning or place Semax early and Selank later. Our Semax vs Selank comparison breaks down where each one fits, and peptides for anxiety puts Selank in context with other options.
Side Effects and Safety
Selank is generally reported as well tolerated at anxiolytic doses. The usual complaints are mild nasal irritation from the spray and occasional fatigue or a flat, blunted feeling at higher doses. It is not FDA-approved, and human safety data outside decades of Russian clinical use is limited, so keeping to the low end of the range and cycling is the reasonable default rather than pushing doses up. This is informational, not medical advice.
Frequently Asked Questions About Selank
The common range is 300 to 900 mcg per day intranasally, split into two or three doses of roughly 300 mcg. Many users start at a single 300 mcg dose to gauge response and add a second or third dose if they want more anxiolytic effect. The registered Russian nasal course uses about 75 mcg per drop, two drops three times daily, which lands near 450 mcg per day.
Reconstitute a 10 mg vial with about 2 mL of bacteriostatic water for a 5 mg/mL solution, then load a fine-mist nasal sprayer. At that strength a 0.1 mL spray delivers roughly 500 mcg, so many users dilute further or use a metered sprayer to land near 300 mcg per application. One application, once to three times daily, is the standard pattern. N-acetyl Selank amidate is the more stable form sold for nasal use.
Yes. Subcutaneous dosing is used in a similar range, roughly 250 to 300 mcg per dose. Injection gives more predictable delivery than the nasal route, where absorption swings with congestion and technique. Most casual users stay with the nasal spray for convenience and reserve injection for when consistent dosing matters.
Selank is not stimulating the way Semax is, so timing is flexible. People use it during the day when anxiety tends to peak, and because it does not cause sedation it can be taken before tasks that need calm focus. A dose can also be placed in the evening without the sleep disruption a stimulating peptide would cause.
The typical cycle mirrors the clinical literature at around 14 days, with some research protocols running to 30 days. Selank does not appear to cause the tolerance or dependence seen with benzodiazepines, so cycling is used more to reassess ongoing benefit than to restore sensitivity. Longer continuous use is reported but has thinner safety data behind it.
Yes, it is the classic pairing. Selank leans calming and anti-anxiety while Semax leans stimulating and focus-oriented, so they offset each other. People run them together in the morning or place Semax early and Selank later in the day. See our Semax vs Selank comparison for how the two differ and how they are combined.
Selank is generally reported as well tolerated. The most common complaints are mild nasal irritation from the spray and occasional fatigue or a flat feeling if dosed high. Because it is not FDA-approved and human safety data outside Russian clinical use is limited, staying at the low end of the range is the sensible default.
The evidence is mostly Russian clinical work. In one 62-patient trial in generalized anxiety and neurasthenia, 14 days of intranasal Selank matched the benzodiazepine medazepam on the Hamilton and Zung anxiety scales but without the sedation or cognitive dulling. It is studied as a modulator of GABAergic tone that also raises BDNF. That is promising but not the same standard of evidence as an FDA-approved anxiolytic.